Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 20/20 | 0.76 |
| ▸ | AURKA | O14965 | 1/20 | 0.65 |
| ▸ | JAK2 | O60674 | 1/20 | 0.65 |
| ▸ | STK16 | O75716 | 1/20 | 0.65 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.65 |
| ▸ | LATS1 | O95835 | 1/20 | 0.65 |
| ▸ | PAK4 | O96013 | 1/20 | 0.65 |
| ▸ | ABL1 | P00519 | 1/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.65 |
| ▸ | CDK1 | P06493 | 1/20 | 0.65 |
| ▸ | LYN | P07948 | 1/20 | 0.65 |
| ▸ | RET | P07949 | 1/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.65 |
| ▸ | FER | P16591 | 1/20 | 0.65 |
| ▸ | FLT1 | P17948 | 1/20 | 0.65 |
| ▸ | ERCC2 | P18074 | 1/20 | 0.65 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.65 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.65 |
| ▸ | DRD1 | P21728 | 1/20 | 0.65 |
| ▸ | CDK2 | P24941 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1628053 | 0.87 | PTK2 (1.00) | PTK2AURKAJAK2STK16CDKL5 | |
| SCHEMBL29853408 | 0.87 | PTK2 (1.00) | PTK2AURKAJAK2STK16CDKL5 | |
| SCHEMBL29853547 | 0.85 | PTK2 (1.00) | PTK2AURKAJAK2STK16CDKL5 | |
| SCHEMBL31653786 | 0.85 | PTK2 (0.87) | PTK2AURKAJAK2STK16CDKL5 | |
| SCHEMBL1628553 | 0.85 | PTK2 (1.00) | PTK2AURKAJAK2STK16CDKL5 | |
| SCHEMBL29853754 | 0.84 | PTK2 (1.00) | PTK2AURKAJAK2STK16CDKL5 | |
| SCHEMBL1626811 | 0.84 | PTK2 (1.00) | PTK2AURKAJAK2STK16CDKL5 | |
| SCHEMBL1628396 | 0.82 | PTK2 (1.00) | PTK2AURKAJAK2STK16CDKL5 | |
| SCHEMBL1626983 | 0.82 | PTK2 (1.00) | PTK2AURKAJAK2STK16CDKL5 | |
| SCHEMBL19583341 | 0.82 | PTK2 (1.00) | PTK2AURKAJAK2STK16CDKL5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020006724-A1 | COMPOUND FOR TARGETED DEGRADATION OF FAK PROTEIN AND USE THEREOF | 清华大学 | 2020-01-09 | — | — | WO | disclosed |