Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 4/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21614731 | 0.89 | CYP2C19 (0.81) | CYP2C19CYP2C9KCNH2MAPTALDH1A1 | |
| SCHEMBL21612033 | 0.88 | CYP2C19 (0.60) | CYP2C19CYP2C9KCNH2PPARDMAPT | |
| SCHEMBL21614667 | 0.80 | CYP2C19 (0.68) | CYP2C19CYP2C9KCNH2MAPTALDH1A1 | |
| SCHEMBL21614772 | 0.79 | CYP2C19 (0.75) | CYP2C19CYP2C9KCNH2CYP3A4CYP1A2 | |
| SCHEMBL21614700 | 0.79 | CYP2C19 (0.66) | CYP2C19CYP2C9KCNH2CYP3A4CYP1A2 | |
| SCHEMBL21614677 | 0.78 | CYP2C19 (0.60) | CYP2C19CYP2C9KCNH2MAPTSMN1; SMN2 | |
| SCHEMBL21614771 | 0.77 | CYP2C19 (0.58) | CYP2C19CYP2C9KCNH2CYP3A4CYP1A2 | |
| SCHEMBL21612045 | 0.74 | CYP2C19 (0.53) | CYP2C19CYP2C9CYP3A4CYP1A2 | |
| SCHEMBL21611951 | 0.72 | CYP2C19 (0.81) | CYP2C19CYP2C9KCNH2MAPTALDH1A1 | |
| SCHEMBL21614741 | 0.70 | CYP2C19 (0.55) | CYP2C19CYP2C9KCNH2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210353606-A1 | PqsR INVERSE AGONISTS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2021-11-18 | — | — | US | disclosed |
| WO-2020007938-A1 | PqsR INVERSE AGONISTS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2020-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210353606-A1 | PqsR INVERSE AGONISTS | QRFPR, P2RY11, QARS1 | CYP2C19 1824/4885CYP2C9 2997/4885KCNH2 2343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.