SCHEMBL21617246

SCHEMBL21617246

O=C(NCCC1CCCC1)c1cccc(Nc2ccc(OCc3ccccn3)cc2C2CC2)c1

nearest known ligand 0.43

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ BRD4 O60885 2/20 0.40
▸ GPR132 Q9UNW8 1/20 0.40
▸ MEN1 O00255 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ CNR2 P34972 1/20 0.39
▸ RHOA P61586 1/20 0.39
▸ MAPK14 Q16539 3/20 0.38
▸ SMO Q99835 3/20 0.38
▸ CHRM4 P08173 2/20 0.38
▸ LDLR P01130 1/20 0.37
▸ SIRT2 Q8IXJ6 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31504340 1.00 BRD4 (0.40) BRD4GPR132MEN1HPGDKMT2A
SCHEMBL31504358 0.99 HPGD (0.40) BRD4GPR132MEN1HPGDKMT2A
SCHEMBL21617185 0.99 HPGD (0.40) BRD4GPR132MEN1HPGDKMT2A
SCHEMBL21617192 0.90 BRD4 (0.42) BRD4GPR132MEN1HPGDKMT2A
SCHEMBL31504367 0.90 BRD4 (0.42) BRD4GPR132MEN1HPGDKMT2A
SCHEMBL31504323 0.90 MAPK14 (0.44) BRD4GPR132MAPK14SMOLDLR
SCHEMBL21617187 0.90 MAPK14 (0.44) BRD4GPR132MAPK14SMOLDLR
SCHEMBL21617270 0.90 CHRM4 (0.40) BRD4MEN1HPGDKMT2ACNR2
SCHEMBL31504437 0.90 CHRM4 (0.40) BRD4MEN1HPGDKMT2ACNR2
SCHEMBL21617173 0.90 BRD4 (0.41) BRD4GPR132MEN1HPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3820850-B1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2026-04-01 — — EP disclosed
US-12421206-B2 Aryl-n-aryl derivatives for treating a RNA virus infection ABIVAX (FR) 2025-09-23 — — US disclosed
EP-3820850-A1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-05-19 — — EP disclosed
US-20210122732-A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-04-29 — — US disclosed
US-20210122732-A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-04-29 — — US disclosed
WO-2020011816-A1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2020-01-16 — — WO disclosed
WO-2020011816-A1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2020-01-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12421206-B2 Aryl-n-aryl derivatives for treating a RNA virus infection NSUN3, CBR3, C1R BRD4 1187/4885GPR132 2767/4885MEN1 3986/4885
US-20210122732-A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION NSUN3, CBR3, C1R BRD4 1187/4885GPR132 2767/4885MEN1 3986/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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