Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.67 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.67 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.67 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.67 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.67 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.67 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.67 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.67 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.67 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14266338 | 0.86 | MAPK14 (0.58) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL14266337 | 0.86 | MAPK14 (0.58) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| Pamapimod SCHEMBL3636701 | 0.80 | MAPK14 (1.00) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| Pamapimod SCHEMBL29429421 | 0.80 | MAPK14 (1.00) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| Pamapimod SCHEMBL29379723 | 0.80 | MAPK14 (1.00) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL5259440 | 0.78 | MAPK14 (0.60) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL13239772 | 0.77 | MAPK14 (0.93) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL2944570 | 0.77 | MAPK14 (0.77) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL2944573 | 0.77 | MAPK14 (0.77) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL22139066 | 0.77 | MAPK14 (0.60) | MAPK14MAPK8MAPK11MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020011661-A1 | COMBINATIONS OF PPAR AGONISTS AND P38 KINASE INHIBITORS FOR PREVENTING OR TREATING FIBROTIC DISEASES | KINARUS AG (CH) | 2020-01-16 | — | — | WO | disclosed |