Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 9/20 | 0.59 |
| ▸ | WIZ | O95785 | 5/20 | 0.54 |
| ▸ | IKZF2 | Q9UKS7 | 6/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25988439 | 0.91 | CRBN (0.70) | CRBNWIZIKZF2 | |
| SCHEMBL21621742 | 0.90 | CRBN (0.58) | CRBNWIZIKZF2 | |
| SCHEMBL25087385 | 0.90 | CRBN (0.54) | CRBNWIZIKZF2 | |
| SCHEMBL24079809 | 0.89 | CRBN (0.56) | CRBNWIZIKZF2 | |
| SCHEMBL24079758 | 0.88 | CRBN (0.53) | CRBNWIZIKZF2 | |
| SCHEMBL26580213 | 0.88 | CRBN (0.66) | CRBNWIZIKZF2 | |
| SCHEMBL22566723 | 0.88 | IKZF2 (0.65) | CRBNWIZIKZF2 | |
| SCHEMBL24080020 | 0.87 | CRBN (0.50) | CRBNWIZIKZF2 | |
| SCHEMBL24816729 | 0.87 | CRBN (0.64) | CRBNWIZIKZF2 | |
| SCHEMBL20442756 | 0.86 | CRBN (0.62) | CRBNWIZIKZF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020012334-A1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2020-01-16 | — | — | WO | disclosed |