Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.94 |
| ▸ | LIFR | P42702 | 3/20 | 0.70 |
| ▸ | PPARD | Q03181 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21636800 | 0.97 | NR1H4 (1.00) | NR1H4LIFR | |
| SCHEMBL28530806 | 0.92 | NR1H4 (1.00) | NR1H4LIFRPPARD | |
| SCHEMBL24425716 | 0.91 | NR1H4 (0.94) | NR1H4LIFRPPARD | |
| SCHEMBL28530665 | 0.90 | NR1H4 (1.00) | NR1H4LIFRPPARD | |
| SCHEMBL21636801 | 0.90 | NR1H4 (0.82) | NR1H4LIFRPPARD | |
| SCHEMBL21636777 | 0.88 | NR1H4 (1.00) | NR1H4LIFRPPARD | |
| SCHEMBL24425718 | 0.88 | NR1H4 (0.79) | NR1H4LIFR | |
| SCHEMBL30080608 | 0.86 | NR1H4 (0.83) | NR1H4LIFR | |
| SCHEMBL30080649 | 0.86 | NR1H4 (0.93) | NR1H4LIFRPPARD | |
| SCHEMBL21636803 | 0.86 | NR1H4 (1.00) | NR1H4LIFRPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3823960-A1 | ISOXAZOLE AS FXR RECEPTOR AGONISTS | Bar Pharmaceuticals Societa ' A Responsabilita' Limitata (IT) | 2021-05-26 | — | — | EP | disclosed |
| WO-2020016801-A1 | ISOXAZOLE AS FXR RECEPTOR AGONISTS | BAR PHARMACEUTICALS SOCIETA' A RESPONSABILITA' LIMITATA (IT) | 2020-01-23 | — | — | WO | disclosed |