Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.68 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.68 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.68 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
| ▸ | EGFR | P00533 | 1/20 | 0.68 |
| ▸ | KRAS | P01116 | 1/20 | 0.68 |
| ▸ | RAF1 | P04049 | 1/20 | 0.68 |
| ▸ | PGR | P06401 | 1/20 | 0.68 |
| ▸ | RET | P07949 | 1/20 | 0.68 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.68 |
| ▸ | ARAF | P10398 | 1/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.68 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.68 |
| ▸ | FECH | P22830 | 1/20 | 0.68 |
| ▸ | KDR | P35968 | 1/20 | 0.68 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.68 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.68 |
| ▸ | NEK2 | P51955 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30866615 | 1.00 | BRAF (0.68) | BRAFMAP3K20MAP4K5RIPK2ABCB11 | |
| SCHEMBL29725806 | 0.94 | BRAF (0.77) | BRAFMAP3K20MAP4K5RIPK2ABCB11 | |
| SCHEMBL20399240 | 0.94 | BRAF (0.77) | BRAFMAP3K20MAP4K5RIPK2ABCB11 | |
| SCHEMBL21624517 | 0.93 | BRAF (0.77) | BRAFMAP3K20MAP4K5RIPK2ABCB11 | |
| SCHEMBL30866641 | 0.93 | BRAF (0.77) | BRAFMAP3K20MAP4K5RIPK2ABCB11 | |
| SCHEMBL21624496 | 0.92 | BRAF (0.72) | BRAFMAP3K20MAP4K5RIPK2ABCB11 | |
| SCHEMBL21625624 | 0.91 | BRAF (0.65) | BRAFMAP3K20MAP4K5RIPK2ABCB11 | |
| SCHEMBL29898534 | 0.91 | BRAF (0.65) | BRAFMAP3K20MAP4K5RIPK2ABCB11 | |
| SCHEMBL30866645 | 0.90 | BRAF (0.74) | BRAFMAP3K20MAP4K5RIPK2ABCB11 | |
| SCHEMBL21624497 | 0.90 | BRAF (0.74) | BRAFMAP3K20MAP4K5RIPK2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220281864-A1 | PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | HEPAREGENIX GMBH (DE) | 2022-09-08 | — | — | US | claimed |
| EP-3823968-A1 | PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | HepaRegeniX GmbH (DE) | 2021-05-26 | — | — | EP | claimed |
| WO-2020016243-A1 | PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | HEPAREGENIX GMBH (DE) | 2020-01-23 | — | — | WO | claimed |
| CN-112424201-B | Protein kinase inhibitors that promote liver regeneration or reduce or prevent hepatocyte death | 海帕瑞吉尼克斯股份有限公司 | 2024-04-02 | — | — | CN | disclosed |
| US-11912701-B2 | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death | HEPAREGENIX GMBH (DE) | 2024-02-27 | — | — | US | disclosed |
| US-11912701-B2 | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death | HEPAREGENIX GMBH (DE) | 2024-02-27 | — | — | US | disclosed |
| US-11912701-B2 | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death | HEPAREGENIX GMBH (DE) | 2024-02-27 | — | — | US | disclosed |
| US-20220281864-A1 | PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | HEPAREGENIX GMBH (DE) | 2022-09-08 | — | — | US | disclosed |
| EP-3823968-A1 | PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | HepaRegeniX GmbH (DE) | 2021-05-26 | — | — | EP | disclosed |
| CN-112424201-A | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death | 海帕瑞吉尼克斯股份有限公司 | 2021-02-26 | — | — | CN | disclosed |
| WO-2020016243-A1 | PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | HEPAREGENIX GMBH (DE) | 2020-01-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912701-B2 | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death | MAPK4, MAPK7, MAPK14 | BRAF 64/4885MAP3K20 49/4885MAP4K5 43/4885 |
| US-20220281864-A1 | PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | MAPK4, MAPK7, MAPK14 | BRAF 65/4885MAP3K20 48/4885MAP4K5 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.