Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP2A1 | O14983 | 5/20 | 0.74 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | XBP1 | P17861 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21632055 | 1.00 | ATP2A1 (0.74) | ATP2A1MAPTNPC1POLBMAPK1 | |
| SCHEMBL17380912 | 0.92 | ATP2A1 (0.78) | ATP2A1MAPTNPC1POLBMAPK1 | |
| SCHEMBL17381173 | 0.92 | ATP2A1 (0.78) | ATP2A1MAPTNPC1POLBMAPK1 | |
| SCHEMBL20521107 | 0.90 | ATP2A1 (0.91) | ATP2A1MAPTNPC1POLBMAPK1 | |
| SCHEMBL20521106 | 0.90 | ATP2A1 (0.91) | ATP2A1MAPTNPC1POLBMAPK1 | |
| SCHEMBL17381112 | 0.86 | ATP2A1 (0.69) | ATP2A1MAPTNPC1POLBMAPK1 | |
| SCHEMBL21631892 | 0.84 | ATP2A1 (0.81) | ATP2A1MAPTNPC1POLBMAPK1 | |
| SCHEMBL21631893 | 0.84 | ATP2A1 (0.81) | ATP2A1MAPTNPC1POLBMAPK1 | |
| SCHEMBL21631891 | 0.84 | ATP2A1 (0.81) | ATP2A1MAPTNPC1POLBMAPK1 | |
| SCHEMBL17381176 | 0.82 | ATP2A1 (0.64) | ATP2A1MAPTNPC1POLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11168064-B2 | Synthesis of thapsigargin, nortrilobolide, and analogs thereof | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2021-11-09 | — | — | US | disclosed |
| US-20200031793-A1 | Synthesis of Thapsigargin, Nortrilobolide, and Analogs Thereof | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2020-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200031793-A1 | Synthesis of Thapsigargin, Nortrilobolide, and Analogs Thereof | HSPA5, ATP2A1, CYP51A1 | ATP2A1 2/4885MAPT 2316/4885NPC1 510/4885 |
| US-11168064-B2 | Synthesis of thapsigargin, nortrilobolide, and analogs thereof | HSPA5, ATP2A1, CYP51A1 | ATP2A1 2/4885MAPT 2316/4885NPC1 510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.