Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ATP2A1 | O14983 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21632245 | 1.00 | MAPT (0.47) | MAPTNPC1POLBMAPK1RAB9A | |
| SCHEMBL21632267 | 0.85 | MAPT (0.61) | MAPTNPC1POLBMAPK1RAB9A | |
| SCHEMBL21632264 | 0.85 | MAPT (0.61) | MAPTNPC1POLBMAPK1RAB9A | |
| SCHEMBL17380894 | 0.84 | MAPT (0.41) | MAPTNPC1POLBMAPK1RAB9A | |
| SCHEMBL21675425 | 0.84 | MAPT (0.47) | MAPTNPC1POLBMAPK1RAB9A | |
| SCHEMBL21632247 | 0.84 | MAPT (0.47) | MAPTNPC1POLBMAPK1RAB9A | |
| SCHEMBL21632248 | 0.84 | MAPT (0.47) | MAPTNPC1POLBMAPK1RAB9A | |
| SCHEMBL21900319 | 0.80 | MAPT (0.70) | MAPTNPC1POLBMAPK1RAB9A | |
| SCHEMBL29791975 | 0.80 | MAPT (0.70) | MAPTNPC1POLBMAPK1RAB9A | |
| SCHEMBL21675306 | 0.80 | MAPT (0.70) | MAPTNPC1POLBMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11168064-B2 | Synthesis of thapsigargin, nortrilobolide, and analogs thereof | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2021-11-09 | — | — | US | disclosed |
| US-11168064-B2 | Synthesis of thapsigargin, nortrilobolide, and analogs thereof | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2021-11-09 | — | — | US | disclosed |
| US-20200031793-A1 | Synthesis of Thapsigargin, Nortrilobolide, and Analogs Thereof | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2020-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200031793-A1 | Synthesis of Thapsigargin, Nortrilobolide, and Analogs Thereof | HSPA5, ATP2A1, CYP51A1 | MAPT 2316/4885NPC1 510/4885POLB 3613/4885 |
| US-11168064-B2 | Synthesis of thapsigargin, nortrilobolide, and analogs thereof | HSPA5, ATP2A1, CYP51A1 | MAPT 2316/4885NPC1 510/4885POLB 3613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.