Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 10/20 | 0.64 |
| ▸ | TTK | P33981 | 4/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.64 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.64 |
| ▸ | AURKA | O14965 | 2/20 | 0.64 |
| ▸ | GPR142 | Q7Z601 | 7/20 | 0.57 |
| ▸ | KIT | P10721 | 3/20 | 0.56 |
| ▸ | SRC | P12931 | 3/20 | 0.56 |
| ▸ | FLT3 | P36888 | 3/20 | 0.56 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10062827 | 0.85 | ITK (0.65) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11351579 | 0.85 | ITK (0.64) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11456181 | 0.84 | ITK (0.67) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11456198 | 0.84 | ITK (0.61) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11456925 | 0.84 | ITK (0.73) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11351031 | 0.83 | ITK (0.62) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL10062811 | 0.82 | ITK (0.68) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11450045 | 0.80 | ITK (0.68) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11363798 | 0.79 | ITK (0.58) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL10062814 | 0.78 | ITK (1.00) | ITKTTKAURKBINCENPAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210187111-A1 | COMPOSITIONS AND METHODS FOR DISRUPTING A MACROPHAGE NETWORK | SCRIPPS HEALTH (US) | 2021-06-24 | — | — | US | disclosed |
| WO-2020018434-A1 | COMPOSITIONS AND METHODS FOR DISRUPTING A MACROPHAGE NETWORK | SCRIPPS HEALTH (US) | 2020-01-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210187111-A1 | COMPOSITIONS AND METHODS FOR DISRUPTING A MACROPHAGE NETWORK | MSR1, CD68, CD209 | ITK 3836/4885TTK 2240/4885AURKB 876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.