Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 10/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20419335 | 0.85 | HTR1B (0.49) | HTR1BTDP1CYP3A4HSD17B10RECQL | |
| SCHEMBL17361703 | 0.79 | HTR1B (0.49) | HTR1BCYP3A4HSD17B10KDM4ECYP2D6 | |
| SCHEMBL19286434 | 0.75 | GAA (0.54) | TDP1CYP3A4HSD17B10L3MBTL1ALDH1A1 | |
| SCHEMBL22658317 | 0.75 | HTR1B (0.41) | HTR1BTDP1CYP3A4HSD17B10KDM4E | |
| SCHEMBL21646370 | 0.71 | ABL1 (0.38) | TDP1CYP3A4HSD17B10RECQLL3MBTL1 | |
| SCHEMBL827229 | 0.71 | HTR1B (0.49) | HTR1BCYP3A4HSD17B10ALDH1A1LMNA | |
| SCHEMBL30286862 | 0.71 | HTR1B (0.49) | HTR1BCYP3A4HSD17B10ALDH1A1LMNA | |
| SCHEMBL826152 | 0.70 | HTR1B (0.45) | HTR1BCYP3A4HSD17B10ALDH1A1LMNA | |
| SCHEMBL22614903 | 0.70 | CYP2A6 (0.42) | HTR1BCYP3A4HSD17B10ALDH1A1LMNA | |
| SCHEMBL22984252 | 0.70 | HTR1B (0.60) | HTR1BCYP3A4HSD17B10KDM4ECYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4104861-A1 | THERAPEUTIC AGENT FOR TAUOPATHIES | Sumitomo Pharma Co., Ltd. (JP) | 2022-12-21 | — | — | EP | disclosed |
| WO-2021149767-A1 | HETEROCYCLIC DERIVATIVE | 大日本住友製薬株式会社 | 2021-07-29 | — | — | WO | disclosed |
| WO-2021039961-A1 | RING-FUSED PYRAZOLE DERIVATIVE | 大日本住友製薬株式会社 | 2021-03-04 | — | — | WO | disclosed |
| WO-2020017587-A1 | PYRIDAZINONE DERIVATIVE | 大日本住友製薬株式会社 | 2020-01-23 | — | — | WO | disclosed |