Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | STING1 | Q86WV6 | 12/20 | 0.50 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19436572 | 0.80 | STING1 (0.78) | NPC1RAB9ARXFP1STING1TBK1 | |
| SCHEMBL19448908 | 0.79 | PTGER4 (0.55) | NPC1RAB9ARXFP1KMT2AMEN1 | |
| SCHEMBL24175826 | 0.76 | STING1 (0.65) | NPC1RAB9ARXFP1KMT2AMEN1 | |
| SCHEMBL19451618 | 0.75 | STING1 (0.80) | NPC1RAB9ARXFP1STING1TBK1 | |
| SCHEMBL23709401 | 0.74 | STING1 (0.56) | NPC1RAB9ARXFP1KMT2AMEN1 | |
| SCHEMBL19436552 | 0.72 | PTGER4 (0.56) | KMT2APTGER4 | |
| SCHEMBL25865649 | 0.72 | STING1 (0.71) | STING1TBK1 | |
| SCHEMBL22135068 | 0.72 | STING1 (0.62) | RXFP1KMT2AMEN1STING1TBK1 | |
| SCHEMBL19451632 | 0.72 | STING1 (0.81) | STING1TBK1 | |
| SCHEMBL29702138 | 0.72 | STING1 (0.81) | STING1TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440072-B1 | HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-01-29 | — | — | EP | disclosed |