Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22474079 | 0.88 | MAP3K5 (0.54) | MAP3K5 | |
| SCHEMBL23048789 | 0.82 | MAP3K5 (0.46) | MAP3K5AKT1 | |
| SCHEMBL21649346 | 0.81 | MAP3K5 (0.50) | MAP3K5 | |
| SCHEMBL21461062 | 0.81 | MAP3K5 (0.55) | MAP3K5AKT1 | |
| SCHEMBL29949159 | 0.81 | MAP3K5 (0.55) | MAP3K5AKT1 | |
| SCHEMBL30433833 | 0.80 | MAP3K5 (0.53) | MAP3K5 | |
| SCHEMBL20557516 | 0.80 | MAP3K5 (0.53) | MAP3K5 | |
| SCHEMBL15143877 | 0.80 | MAP3K5 (0.65) | MAP3K5 | |
| Hydrochloric Acid SCHEMBL15136406 | 0.79 | MAP3K5 (0.64) | MAP3K5 | |
| Water SCHEMBL28514353 | 0.79 | MAP3K5 (0.64) | MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3572401-B1 | ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | FUJIAN COSUNTER PHARMACEUTICAL CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |
| US-11040968-B2 | Pyridine derivative as ASK1 inhibitor and preparation method and use thereof | FUJIAN AKEYLINK BIOTECHNOLOGY CO., LTD. (CN) | 2021-06-22 | — | — | US | disclosed |
| EP-3572412-B1 | PYRIDINE DERIVATIVE AS ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | FUJIAN COSUNTER PHARMACEUTICAL CO LTD (CN) | 2021-03-03 | — | — | EP | disclosed |
| US-10787435-B2 | ASK1 inhibitor and preparation method and use thereof | Fuijan Cosunter Pharmaceutical Co. Ltd. (CN) | 2020-09-29 | — | — | US | disclosed |
| US-20200031823-A1 | PYRIDINE DERIVATIVE AS ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | FUJUAN COSUNTER PHARMACEUTICAL CO., LTD. (CN) | 2020-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11040968-B2 | Pyridine derivative as ASK1 inhibitor and preparation method and use thereof | MARK1, MAP3K1, MAP3K11 | MAP3K5 5/4885AKT1 570/4885 |
| US-10787435-B2 | ASK1 inhibitor and preparation method and use thereof | MARK1, MAP3K1, MAP3K20 | MAP3K5 10/4885AKT1 250/4885 |
| US-20200031823-A1 | PYRIDINE DERIVATIVE AS ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | MARK1, MAP3K1, MAP3K11 | MAP3K5 5/4885AKT1 570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.