Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29542772 | 0.89 | KDM4E (0.44) | KDM4EKMT2ACHRNB2CHRNA7CHRNA4 | |
| SCHEMBL23866531 | 0.80 | POLB (0.37) | KDM4EKMT2ACHRNB2CHRNA7CHRNA4 | |
| SCHEMBL21661348 | 0.79 | CYP1A2 (0.42) | KDM4EKMT2ACHRNB2CHRNA7CHRNA4 | |
| SCHEMBL23866610 | 0.79 | CYP1A2 (0.42) | KDM4EKMT2ACHRNB2CHRNA7CHRNA4 | |
| SCHEMBL24690286 | 0.78 | — | — | |
| SCHEMBL24690289 | 0.78 | — | — | |
| SCHEMBL21661207 | 0.78 | CYP2D6 (0.38) | KDM4EKMT2A | |
| SCHEMBL23866602 | 0.78 | CYP2D6 (0.38) | KDM4EKMT2A | |
| SCHEMBL23866605 | 0.78 | CYP2D6 (0.38) | KDM4EKMT2A | |
| SCHEMBL21776649 | 0.78 | NPSR1 (0.34) | KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020025517-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2020-02-06 | — | — | WO | disclosed |