Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 7/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | USP14 | P54578 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21661573 | 1.00 | TLR9 (0.46) | TLR9TLR8TLR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL21661161 | 0.95 | TLR9 (0.45) | TLR9TLR8TLR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL21661571 | 0.95 | TLR9 (0.45) | TLR9TLR8TLR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL23855159 | 0.95 | TLR9 (0.45) | TLR9TLR8TLR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL21660929 | 0.91 | TLR8 (0.44) | TLR9TLR8TLR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL21660930 | 0.91 | TLR8 (0.44) | TLR9TLR8TLR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL21661162 | 0.90 | TLR8 (0.45) | TLR9TLR8TLR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL16633950 | 0.89 | TLR8 (0.49) | TLR9TLR8TLR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL16633952 | 0.89 | TLR8 (0.49) | TLR9TLR8TLR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL21661163 | 0.88 | TLR9 (0.49) | TLR9TLR8TLR7ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020025517-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2020-02-06 | — | — | WO | disclosed |