Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 4/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20716038 | 0.89 | CYP3A4 (0.61) | CYP3A4CYP2B6TP53MEN1KMT2A | |
| SCHEMBL21667381 | 0.84 | PDE5A (0.48) | CYP3A4CYP2B6MEN1KMT2AMAPT | |
| SCHEMBL16321947 | 0.84 | CYP3A4 (0.71) | CYP3A4CYP2B6NPC1RAB9AL3MBTL1 | |
| SCHEMBL16321946 | 0.84 | CYP3A4 (0.71) | CYP3A4CYP2B6NPC1RAB9AL3MBTL1 | |
| SCHEMBL21667273 | 0.80 | SMN1; SMN2 (0.44) | CYP3A4CYP2B6TP53MEN1KMT2A | |
| SCHEMBL21667332 | 0.79 | CYP3A4 (0.49) | CYP3A4CYP2B6TP53MEN1KMT2A | |
| SCHEMBL21667252 | 0.79 | PDE9A (0.50) | CYP3A4CYP2B6MEN1KMT2AMAPT | |
| SCHEMBL21667374 | 0.78 | CYP3A4 (0.52) | CYP3A4CYP2B6TP53MEN1KMT2A | |
| SCHEMBL21667347 | 0.77 | CYP3A4 (0.50) | CYP3A4CYP2B6TP53MEN1KMT2A | |
| SCHEMBL21667210 | 0.77 | SMN1; SMN2 (0.47) | CYP3A4CYP2B6TP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |