Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | PDE9A | O76083 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | HK1 | P19367 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20716038 | 0.85 | CYP3A4 (0.61) | KMT2AMEN1PDE9ACYP3A4CYP2B6 | |
| SCHEMBL21667347 | 0.81 | CYP3A4 (0.50) | KMT2AMEN1PDE9ACYP3A4CYP2B6 | |
| SCHEMBL21667306 | 0.81 | CYP3A4 (0.50) | KMT2AMEN1PDE9ACYP3A4CYP2B6 | |
| SCHEMBL21667374 | 0.80 | CYP3A4 (0.52) | KMT2AMEN1PDE9ACYP3A4CYP2B6 | |
| SCHEMBL21667309 | 0.80 | CYP3A4 (0.49) | KMT2AMEN1PDE9ACYP3A4CYP2B6 | |
| SCHEMBL21667176 | 0.80 | CYP3A4 (0.49) | KMT2AMEN1CYP3A4CYP2B6L3MBTL1 | |
| SCHEMBL21667252 | 0.78 | PDE9A (0.50) | KMT2AMEN1PDE9ACYP3A4CYP2B6 | |
| SCHEMBL21667332 | 0.78 | CYP3A4 (0.49) | KMT2AMEN1CYP3A4CYP2B6POLB | |
| SCHEMBL16321586 | 0.77 | CYP3A4 (0.73) | KMT2AMEN1CYP3A4CYP2B6KDM4E | |
| SCHEMBL16321585 | 0.77 | CYP3A4 (0.73) | KMT2AMEN1CYP3A4CYP2B6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |