Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CDC25B | P30305 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22639826 | 0.81 | SMN1; SMN2 (0.74) | SMN1; SMN2TP53CDC25BKMT2AMEN1 | |
| SCHEMBL21667215 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2TP53CDC25BKMT2AMEN1 | |
| SCHEMBL21667187 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2TP53CDC25BKMT2AMEN1 | |
| SCHEMBL20716038 | 0.78 | CYP3A4 (0.61) | SMN1; SMN2TP53CDC25BKMT2AMEN1 | |
| SCHEMBL21667343 | 0.77 | MEN1 (0.61) | SMN1; SMN2TP53CDC25BKMT2AMEN1 | |
| SCHEMBL21667214 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2TP53CDC25BKMT2AMEN1 | |
| SCHEMBL21667210 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2TP53CDC25BKMT2AMEN1 | |
| SCHEMBL21667361 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2TP53CDC25BKMT2AMEN1 | |
| SCHEMBL21667373 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2TP53CDC25BKMT2AMEN1 | |
| SCHEMBL21667366 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2TP53CDC25BKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |