Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667339 | 0.86 | CYP3A4 (0.46) | CYP3A4CYP2B6MEN1KMT2APGR | |
| SCHEMBL21667279 | 0.86 | CYP3A4 (0.54) | CYP3A4CYP2B6MAPTKMT2ACYP2C19 | |
| SCHEMBL21667323 | 0.86 | CYP3A4 (0.54) | CYP3A4CYP2B6MEN1KMT2ACYP2C9 | |
| SCHEMBL21667264 | 0.86 | CYP3A4 (0.51) | CYP3A4CYP2B6MAPTKDM4EMEN1 | |
| SCHEMBL21667350 | 0.85 | CYP3A4 (0.53) | CYP3A4CYP2B6MAPTGAAKDM4E | |
| SCHEMBL21667363 | 0.84 | CYP3A4 (0.50) | CYP3A4CYP2B6 | |
| SCHEMBL21667335 | 0.83 | CYP3A4 (0.51) | CYP3A4CYP2B6MAPTGAAKDM4E | |
| SCHEMBL21667318 | 0.82 | CYP3A4 (0.50) | CYP3A4CYP2B6PGRL3MBTL1ALDH1A1 | |
| SCHEMBL20716038 | 0.82 | CYP3A4 (0.61) | CYP3A4CYP2B6MAPTKDM4EMEN1 | |
| SCHEMBL21667332 | 0.80 | CYP3A4 (0.49) | CYP3A4CYP2B6MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |