Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CDC25B | P30305 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667343 | 0.82 | MEN1 (0.61) | MEN1KMT2ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL21667192 | 0.82 | MEN1 (0.53) | MEN1KMT2ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL21667385 | 0.81 | MEN1 (0.47) | MEN1KMT2ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL21667360 | 0.76 | SMN1; SMN2 (0.47) | MEN1KMT2ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL21667268 | 0.76 | MEN1 (0.60) | MEN1KMT2ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL21667266 | 0.76 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL22639826 | 0.75 | SMN1; SMN2 (0.74) | MEN1KMT2ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL21667325 | 0.75 | MEN1 (0.51) | MEN1KMT2ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL16322520 | 0.75 | SMN1; SMN2 (0.63) | MEN1KMT2ASMN1; SMN2MAPK13MAPK12 | |
| SCHEMBL16322521 | 0.75 | SMN1; SMN2 (0.63) | MEN1KMT2ASMN1; SMN2MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |