Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 19/20 | 0.61 |
| ▸ | KLK1 | P06870 | 6/20 | 0.55 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.52 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.52 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14485476 | 1.00 | KLKB1 (0.61) | KLKB1KLK1PSMB1PSMB9PSMB10 | |
| SCHEMBL14485437 | 0.88 | KLKB1 (0.64) | KLKB1KLK1 | |
| SCHEMBL14485441 | 0.88 | KLKB1 (0.64) | KLKB1KLK1 | |
| SCHEMBL14485398 | 0.88 | KLKB1 (0.70) | KLKB1KLK1 | |
| SCHEMBL14485400 | 0.88 | KLKB1 (0.70) | KLKB1KLK1 | |
| SCHEMBL14554987 | 0.87 | KLKB1 (0.79) | KLKB1KLK1 | |
| Benzene SCHEMBL14486117 | 0.87 | KLKB1 (0.79) | KLKB1KLK1 | |
| SCHEMBL15901012 | 0.87 | KLKB1 (0.61) | KLKB1KLK1PSMB1PSMB9PSMB10 | |
| SCHEMBL17268092 | 0.87 | KLKB1 (0.61) | KLKB1KLK1PSMB1PSMB9PSMB10 | |
| SCHEMBL14485405 | 0.86 | KLKB1 (0.64) | KLKB1KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729443-B3 | BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LTD (GB) | 2020-02-12 | — | — | EP | disclosed |