Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170216 | 0.92 | NPC1 (0.43) | NPC1RAB9AKMT2AMAOBMEN1 | |
| SCHEMBL18887228 | 0.89 | USP30 (0.37) | NPC1RAB9AKMT2AMAOBMEN1 | |
| SCHEMBL2170320 | 0.87 | NPC1 (0.44) | NPC1RAB9AKMT2AMAOBMEN1 | |
| SCHEMBL2201301 | 0.86 | SMN1; SMN2 (0.40) | NPC1RAB9AKMT2AMEN1USP30 | |
| SCHEMBL4419952 | 0.84 | USP30 (0.49) | NPC1RAB9AKMT2AMAOBMEN1 | |
| SCHEMBL2169218 | 0.83 | KMT2A (0.42) | NPC1RAB9AKMT2AMAOBMEN1 | |
| SCHEMBL2169077 | 0.82 | KMT2A (0.44) | NPC1RAB9AKMT2AMAOBMEN1 | |
| SCHEMBL2180812 | 0.81 | NPC1 (0.43) | NPC1RAB9AKMT2AMAOBMEN1 | |
| SCHEMBL18887312 | 0.81 | USP30 (0.39) | NPC1RAB9AKMT2AMAOBMEN1 | |
| SCHEMBL2226067 | 0.81 | USP30 (0.38) | NPC1RAB9AMAOBUSP30SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4732354-B2 | — | — | 2011-07-27 | — | — | JP | claimed |