Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 16/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 16/20 | 0.42 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21682243 | 0.85 | PRMT5 (0.40) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL18572035 | 0.80 | PI4KA (0.55) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL28439637 | 0.78 | PRMT5 (0.41) | PRMT5WDR77 | |
| SCHEMBL22001980 | 0.76 | PRMT5 (0.42) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL31228450 | 0.74 | PRMT5 (0.45) | PRMT5WDR77 | |
| SCHEMBL31228186 | 0.74 | PRMT5 (0.46) | PRMT5WDR77 | |
| SCHEMBL22682119 | 0.73 | RXFP1 (0.41) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL28438196 | 0.73 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL3769785 | 0.72 | PRMT5 (0.46) | PRMT5WDR77 | |
| SCHEMBL13005619 | 0.72 | PRMT5 (0.46) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230062119-A1 | USE OF BIOMARKERS IN IDENTIFYING PATIENTS THAT WILL BE RESPONSIVE TO TREATMENT WITH A PRMT5 INHIBITOR | MERCK SHARP & DOHME LLC (US) | 2023-03-02 | — | — | US | disclosed |
| WO-2021126999-A1 | USE OF BIOMARKERS IN IDENTIFYING PATIENTS THAT WILL BE RESPONSIVE TO TREATMENT WITH A PRMT5 INHIBITOR | MERCK SHARP & DOHME CORP. (US) | 2021-06-24 | — | — | WO | disclosed |
| EP-3833355-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-06-16 | — | — | EP | disclosed |
| WO-2020033288-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | WO | disclosed |