Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169453 | 0.95 | NPC1 (0.40) | NPC1RAB9AKMT2AMAOBPKM | |
| SCHEMBL2168634 | 0.94 | KMT2A (0.43) | NPC1RAB9AKMT2AMAOBPKM | |
| SCHEMBL2169061 | 0.90 | KMT2A (0.43) | NPC1RAB9AKMT2AMAOBPKM | |
| SCHEMBL2168916 | 0.89 | KMT2A (0.42) | NPC1RAB9AKMT2AMAOBPKM | |
| SCHEMBL2177825 | 0.89 | KMT2A (0.45) | NPC1RAB9AKMT2AMAOBPKM | |
| SCHEMBL18887340 | 0.89 | GAA (0.36) | NPC1RAB9AKMT2AMAOBPKM | |
| SCHEMBL2168043 | 0.89 | NPC1 (0.43) | NPC1RAB9AKMT2AMAOBPKM | |
| SCHEMBL2167129 | 0.88 | KMT2A (0.41) | NPC1RAB9AKMT2AMAOBPKM | |
| SCHEMBL2169110 | 0.88 | KMT2A (0.44) | NPC1RAB9AKMT2AMAOBPKM | |
| SCHEMBL2168988 | 0.88 | KMT2A (0.44) | NPC1RAB9AKMT2AMAOBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4732354-B2 | — | — | 2011-07-27 | — | — | JP | claimed |