Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16254937 | 0.95 | GAA (0.50) | GAATSHRMAPTPIK3CDRECQL | |
| SCHEMBL22893351 | 0.87 | MAPT (0.59) | GAATSHRMAPTRECQLHPGD | |
| SCHEMBL15730586 | 0.85 | GAA (0.64) | GAATSHRMAPTRECQLHPGD | |
| SCHEMBL6185245 | 0.85 | GAA (0.64) | GAATSHRMAPTRECQLHPGD | |
| SCHEMBL15730093 | 0.85 | GAA (0.64) | GAATSHRMAPTRECQLHPGD | |
| SCHEMBL16254691 | 0.81 | GAA (0.64) | GAATSHRMAPTRECQLHPGD | |
| SCHEMBL12809310 | 0.81 | GAA (0.59) | GAATSHRMAPTRECQLHPGD | |
| SCHEMBL19070467 | 0.81 | CA12 (0.49) | GAATSHRMAPTPIK3CDRECQL | |
| SCHEMBL16254880 | 0.79 | TSHR (0.66) | GAATSHRMAPTRECQLHPGD | |
| SCHEMBL9093412 | 0.79 | TSHR (0.66) | GAATSHRMAPTRECQLHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3608317-A1 | COMPOUNDS & METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS & OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE | Yale University (US) | 2020-02-12 | — | — | EP | disclosed |