SCHEMBL21696680

SCHEMBL21696680

Cc1cc(CC(=O)N2CC(O)C[C@H]2C(=O)NCc2ccc(Cl)cc2)on1

nearest known ligand 0.82

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ VHL P40337 19/20 0.82
▸ ELOC Q15369 6/20 0.73
▸ ELOB Q15370 6/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16277195 1.00 VHL (0.82) VHLELOCELOB
SCHEMBL15125974 1.00 VHL (0.82) VHLELOCELOB
SCHEMBL15126365 0.93 VHL (0.76) VHLELOCELOB
SCHEMBL15125860 0.91 VHL (0.79) VHLELOCELOB
SCHEMBL21697390 0.91 VHL (0.69) VHLELOCELOB
SCHEMBL15126072 0.91 VHL (0.69) VHLELOCELOB
SCHEMBL15125901 0.91 VHL (0.79) VHLELOCELOB
SCHEMBL15125903 0.91 VHL (0.69) VHLELOCELOB
SCHEMBL15125926 0.91 VHL (0.73) VHLELOCELOB
SCHEMBL15125933 0.91 VHL (0.73) VHLELOCELOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3608317-A1 COMPOUNDS & METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS & OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE Yale University (US) 2020-02-12 — — EP disclosed
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