Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15126131 | 0.84 | VHL (0.50) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL15125915 | 0.84 | VHL (0.59) | MAPT | |
| SCHEMBL21696687 | 0.83 | VHL (0.59) | POLBMEN1KMT2APKMCYP3A4 | |
| SCHEMBL15126261 | 0.83 | VHL (0.59) | POLBMEN1KMT2APKMCYP3A4 | |
| SCHEMBL16277211 | 0.81 | VHL (0.57) | POLBMEN1KMT2APKMCYP3A4 | |
| SCHEMBL21697275 | 0.79 | POLB (0.49) | POLBMEN1KMT2APKMCYP3A4 | |
| SCHEMBL16277175 | 0.79 | POLB (0.51) | POLBMEN1KMT2APKMCYP3A4 | |
| SCHEMBL22291794 | 0.78 | POLB (0.52) | POLBMEN1KMT2APKMCYP3A4 | |
| SCHEMBL21696530 | 0.78 | CYP3A4 (0.59) | POLBMEN1KMT2APKMCYP3A4 | |
| SCHEMBL16277225 | 0.77 | POLB (0.51) | POLBMEN1KMT2APKMCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3608317-A1 | COMPOUNDS & METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS & OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE | Yale University (US) | 2020-02-12 | — | — | EP | disclosed |