Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 20/20 | 0.65 |
| ▸ | AURKA | O14965 | 17/20 | 0.65 |
| ▸ | AURKC | Q9UQB9 | 5/20 | 0.65 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2161109 | 0.92 | AURKB (0.56) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2146309 | 0.91 | AURKB (0.55) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2948567 | 0.89 | AURKB (0.64) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2160263 | 0.86 | AURKB (0.68) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2148590 | 0.84 | AURKA (0.55) | AURKBAURKAAURKC | |
| SCHEMBL2224220 | 0.83 | AURKA (0.69) | AURKBAURKA | |
| SCHEMBL2162306 | 0.83 | AURKA (0.60) | AURKBAURKA | |
| SCHEMBL2171510 | 0.83 | AURKA (0.69) | AURKBAURKA | |
| SCHEMBL13221224 | 0.83 | AURKB (0.57) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2150067 | 0.82 | AURKB (0.56) | AURKBAURKAAURKC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | claimed |
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |