Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.58 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.58 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.56 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.56 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.56 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.56 |
| ▸ | LDHA | P00338 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | FBP1 | P09467 | 1/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.56 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.56 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13259507 | 1.00 | POLB (0.61) | POLBP2RY1ENPP1SRCP2RY2 | |
| SCHEMBL16691022 | 0.96 | POLB (0.61) | POLBP2RY1ENPP1SRCP2RY2 | |
| SCHEMBL17122140 | 0.93 | POLB (0.58) | POLBP2RY1ENPP1SRCP2RY2 | |
| SCHEMBL18311990 | 0.93 | POLB (0.61) | POLBP2RY1ENPP1SRCP2RY2 | |
| SCHEMBL16919748 | 0.93 | POLB (0.61) | POLBP2RY1ENPP1SRCP2RY2 | |
| SCHEMBL16920517 | 0.93 | POLB (0.61) | POLBP2RY1ENPP1SRCP2RY2 | |
| SCHEMBL20643550 | 0.92 | POLB (0.57) | POLBP2RY1ENPP1SRCP2RY2 | |
| SCHEMBL23790957 | 0.92 | POLB (0.57) | POLBP2RY1ENPP1SRCP2RY2 | |
| SCHEMBL16691001 | 0.92 | POLB (0.57) | POLBP2RY1ENPP1SRCP2RY2 | |
| SCHEMBL26068420 | 0.91 | POLB (0.59) | POLBP2RY1ENPP1SRCP2RY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4223315-A2 | METHOD FOR SYNTHESIS OF REACTIVE CONJUGATE CLUSTERS | Ionis Pharmaceuticals, Inc. (US) | 2023-08-09 | — | — | EP | disclosed |
| EP-4219718-A2 | COMPOSITIONS AND METHODS FOR MODULATING COMPLEMENT FACTOR B EXPRESSION | Ionis Pharmaceuticals, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-3862362-A2 | CONJUGATES OF MODIFIED ANTISENSE OLIGONUCLEOTIDES AND THEIR USE FOR MODULATING PKK EXPRESSION | Ionis Pharmaceuticals, Inc. (US) | 2021-08-11 | — | — | EP | disclosed |
| EP-3811977-A1 | METHOD FOR SYNTHESIS OF REACTIVE CONJUGATE CLUSTERS | Ionis Pharmaceuticals, Inc. (US) | 2021-04-28 | — | — | EP | disclosed |
| EP-3690049-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION | Ionis Pharmaceuticals, Inc. (US) | 2020-08-05 | — | — | EP | disclosed |
| EP-3608406-A1 | COMPOSITIONS AND METHODS FOR MODULATING COMPLEMENT FACTOR B EXPRESSION | Ionis Pharmaceuticals, Inc. (US) | 2020-02-12 | — | — | EP | disclosed |