Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.64 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.60 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.55 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10168782 | 0.84 | HRH3 (0.70) | HRH3SLC6A5ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL10168794 | 0.83 | HRH3 (0.67) | HRH3SLC6A5ALDH1A1KMT2A | |
| SCHEMBL22643851 | 0.83 | HRH3 (0.67) | HRH3SLC6A5ALDH1A1KMT2A | |
| SCHEMBL20147538 | 0.83 | HRH3 (0.67) | HRH3SLC6A5ALDH1A1KMT2A | |
| SCHEMBL23384263 | 0.81 | SMYD3 (0.57) | HRH3SMYD3ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL10211612 | 0.81 | HRH3 (0.65) | HRH3SLC6A5 | |
| SCHEMBL19294705 | 0.79 | SMYD3 (0.49) | HRH3SMYD3HDAC6MAPTUSP2 | |
| SCHEMBL19282428 | 0.79 | SMYD3 (0.49) | HRH3SMYD3HDAC6MAPTUSP2 | |
| SCHEMBL19282464 | 0.79 | SMYD3 (0.49) | HRH3SMYD3HDAC6MAPTUSP2 | |
| SCHEMBL19282434 | 0.79 | SMYD3 (0.49) | HRH3SMYD3HDAC6MAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200048195-A1 | SUBSTITUTED PYRROLIDINE CARBOXAMIDE COMPOUNDS | Epizyme, Inc. | 2020-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048195-A1 | SUBSTITUTED PYRROLIDINE CARBOXAMIDE COMPOUNDS | SMYD3, SMYD2, SMURF2 | HRH3 2070/4885SMYD3 1/4885SLC6A5 2786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.