Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.67 |
| ▸ | BTK | Q06187 | 2/20 | 0.61 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21701310 | 1.00 | JAK3 (0.67) | JAK3BTKIRAK4 | |
| SCHEMBL21704983 | 0.88 | BTK (0.58) | JAK3BTK | |
| SCHEMBL30046371 | 0.88 | BTK (0.58) | JAK3BTK | |
| SCHEMBL21701349 | 0.88 | BTK (0.58) | JAK3BTK | |
| SCHEMBL21701264 | 0.86 | BTK (0.67) | JAK3BTK | |
| SCHEMBL21704903 | 0.86 | BTK (0.67) | JAK3BTK | |
| SCHEMBL21678464 | 0.86 | JAK3 (0.75) | JAK3IRAK4 | |
| SCHEMBL21678465 | 0.86 | JAK3 (0.75) | JAK3IRAK4 | |
| SCHEMBL21701293 | 0.85 | JAK3 (0.61) | JAK3BTK | |
| SCHEMBL21705070 | 0.85 | BTK (0.68) | JAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033955-A1 | PYRROLOPYRIMIDINE ITK INHIBITORS | ACLARIS THERAPEUTICS, INC. (US) | 2020-02-13 | — | — | WO | disclosed |