Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 12/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TSPO | P30536 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4181122 | 0.86 | PIK3CD (0.54) | PIK3CDATMMGAMGAASI | |
| SCHEMBL10250927 | 0.86 | PIK3CD (0.65) | PIK3CDATMTSPOMEN1KMT2A | |
| SCHEMBL1880588 | 0.82 | ATM (0.45) | PIK3CDATMTSHRALDH1A1GAA | |
| SCHEMBL4176627 | 0.81 | PIK3CD (0.68) | PIK3CDATMCYP3A4ALDH1A1MGAM | |
| SCHEMBL1886097 | 0.77 | PIK3CD (0.64) | PIK3CDATMMEN1KMT2AMGAM | |
| SCHEMBL4443126 | 0.77 | PIK3CD (0.52) | PIK3CDATMMGAMGAASI | |
| SCHEMBL1597713 | 0.76 | PIK3CD (0.65) | PIK3CDATMMGAMGAASI | |
| SCHEMBL12014774 | 0.76 | PIK3CD (0.65) | PIK3CDATMMGAMGAASI | |
| SCHEMBL4181767 | 0.75 | ATM (0.55) | PIK3CDATM | |
| SCHEMBL1312945 | 0.74 | PIK3CD (0.64) | PIK3CDATMMGAMGAASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200048265-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2020-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048265-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, BCL9, MALT1 | PIK3CD 16/4885ATM 750/4885TSPO 1929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.