Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 8/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.76 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.76 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.76 |
| ▸ | MAPT | P10636 | 3/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | TP53 | P04637 | 2/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | HPGD | P15428 | 1/20 | 0.76 |
| ▸ | CLK1 | P49759 | 1/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.76 |
| ▸ | CDK5 | Q00535 | 13/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 13/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminopurvalanol SCHEMBL29386084 | 0.86 | CDK1 (1.00) | CDK1KDM4ECCNB2ALDH1A1CCNB1 | |
| Aminopurvalanol SCHEMBL2170683 | 0.86 | CDK1 (1.00) | CDK1KDM4ECCNB2ALDH1A1CCNB1 | |
| Aminopurvalanol SCHEMBL23752328 | 0.86 | CDK1 (1.00) | CDK1KDM4ECCNB2ALDH1A1CCNB1 | |
| Aminopurvalanol SCHEMBL21168739 | 0.86 | CDK1 (1.00) | CDK1KDM4ECCNB2ALDH1A1CCNB1 | |
| SCHEMBL3444580 | 0.82 | CDK1 (0.70) | CDK1KDM4ECCNB2ALDH1A1CCNB1 | |
| SCHEMBL3444585 | 0.82 | CDK1 (0.70) | CDK1KDM4ECCNB2ALDH1A1CCNB1 | |
| SCHEMBL17603568 | 0.80 | CDK5 (0.78) | CDK1KDM4ECCNB2ALDH1A1CCNB1 | |
| SCHEMBL3444842 | 0.80 | CDK1 (0.67) | CDK1KDM4ECCNB2ALDH1A1CCNB1 | |
| SCHEMBL3444849 | 0.80 | CDK1 (0.67) | CDK1KDM4ECCNB2ALDH1A1CCNB1 | |
| SCHEMBL3445809 | 0.79 | CDK1 (0.71) | CDK1KDM4ECCNB2ALDH1A1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346988-A1 | DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TO THE PANCREATIC ENDOCRINE LINEAGE | Centocor Ortho Biotech Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010051223-A1 | DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TO THE PANCREATIC ENDOCRINE LINEAGE | CENTOCOR ORTHO BIOTECH INC. (US) | 2010-05-06 | — | — | WO | disclosed |