⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4843148 | 0.69 | — | — | |
| SCHEMBL6277353 | 0.69 | — | — | |
| SCHEMBL7931429 | 0.69 | — | — | |
| SCHEMBL87533 | 0.68 | — | — | |
| SCHEMBL1093984 | 0.65 | — | — | |
| SCHEMBL7462321 | 0.65 | AKT2 (0.39) | — | |
| SCHEMBL694420 | 0.65 | — | — | |
| SCHEMBL1132279 | 0.64 | — | — | |
| SCHEMBL1093982 | 0.63 | — | — | |
| SCHEMBL17048391 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102482234-A | Nitrogen-containing compounds and pharmaceutical compositions | OTSUKA PHARMA CO LTD | 2012-05-30 | — | — | CN | claimed |
| CN-102203089-A | N-sulfonylamino polycyclic pyrazolyl compounds | ELAN PHARM INC | 2011-09-28 | — | — | CN | claimed |
| EP-2346863-A2 | N-SULFONAMIDO POLYCYCLIC PYRAZOLYL COMPOUNDS | Elan Pharmaceuticals Inc. (US) | 2011-07-27 | — | — | EP | claimed |
| CN-101821256-A | Novel heterocyclic compounds as mGlu5 antagonists | RECORDATI IRELAND LTD | 2010-09-01 | — | — | CN | claimed |
| US-20100081680-A1 | N-SULFONAMIDO POLYCYCLIC PYRAZOLYL COMPOUNDS | ELAN PHARMACEUTICALS, INC. | 2010-04-01 | — | — | US | claimed |
| WO-2010028213-A2 | N-SULFONAMIDO POLYCYCLIC PYRAZOLYL COMPOUNDS | ELAN PHARMACEUTICALS, INC. (US) | 2010-03-11 | — | — | WO | claimed |
| CN-101443323-A | Substituted spirocyclic CGRP receptor antagonists | MERCK & CO INC (US) | 2009-05-27 | — | — | CN | claimed |
| EP-1705179-A1 | N-aroyl cyclic amine derivatives as orexin receptor antagonists | SMITHKLINE BEECHAM PLC (GB) | 2006-09-27 | — | — | EP | claimed |
| EP-1399441-B1 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2006-07-05 | — | — | EP | claimed |
| US-20040180887-A1 | N-aroyl cyclic amine derivatives as orexin receptor antagonists | SMITHKLINE BEECHAM LIMITED (GB) | 2004-09-16 | — | — | US | claimed |
| EP-1399441-A1 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-03-24 | — | — | EP | claimed |
| WO-2003002561-A1 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-01-09 | — | — | WO | claimed |
| CN-102947319-A | A process for the reduction of a tertiary phosphine oxide to the corresponding tertiary phosphine in the presence of a catalyst and use of a tertiary phosphine for reducing a tertiary phosphine oxide in the presence of a catalyst | CHROMAFORA AB | 2013-02-27 | — | — | CN | disclosed |
| US-8283358-B2 | N-sulfonamido polycyclic pyrazolyl compounds | ELAN PHARMACEUTICALS, INC. (US) | 2012-10-09 | — | — | US | disclosed |
| CN-102482234-A | Nitrogen-containing compounds and pharmaceutical compositions | OTSUKA PHARMA CO LTD | 2012-05-30 | — | — | CN | disclosed |
| CN-102459179-A | Pyridinone antagonists of alpha-4 integrins | ELAN PHARM INC | 2012-05-16 | — | — | CN | disclosed |
| CN-1362409-A | 2-phenoxy pyrimidine derivative and its use in treating disease | CHEN YIJUN CN | 2002-08-07 | — | — | CN | disclosed |
| US-20020086886-A1 | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors | G.D. SEARLE & CO. | 2002-07-04 | — | — | US | disclosed |
| CN-1067054-C | 1H-indole-3-glyoxylamide spla2 inhibitors | LILLY CO ELI (US) | 2001-06-13 | — | — | CN | disclosed |
| CN-1114310-A | 1H-indole-3-glyoxylamide sPLA2Inhibitors | LILLY CO ELI (US) | 1996-01-03 | — | — | CN | disclosed |