Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.69 |
| ▸ | THRB | P10828 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 4/20 | 0.66 |
| ▸ | TP53 | P04637 | 4/20 | 0.63 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172534 | 0.87 | MAPT (0.68) | MAPTTHRBPOLBTP53NPC1 | |
| SCHEMBL2549009 | 0.85 | POLB (0.68) | MAPTTHRBPOLBTP53MEN1 | |
| SCHEMBL2171108 | 0.85 | MAPT (0.79) | MAPTTHRBPOLBTP53MEN1 | |
| SCHEMBL2542966 | 0.84 | MAPT (0.70) | MAPTTHRBPOLBTP53MEN1 | |
| SCHEMBL2547296 | 0.84 | MAPT (0.69) | MAPTTHRBPOLBTP53MEN1 | |
| SCHEMBL2186610 | 0.82 | MAPT (0.72) | MAPTPOLBTP53KDM4ENPC1 | |
| SCHEMBL2172878 | 0.81 | TP53 (0.68) | MAPTTHRBPOLBTP53 | |
| SCHEMBL2547306 | 0.81 | MAPT (0.79) | MAPTTHRBPOLBTP53MEN1 | |
| SCHEMBL2173312 | 0.78 | MAPT (0.61) | MAPTTHRBPOLBTP53MEN1 | |
| SCHEMBL2542223 | 0.78 | MAPT (0.66) | MAPTPOLBTP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346832-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | Glaxo Group Limited (GB) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | disclosed |