Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 7/20 | 0.47 |
| ▸ | DBF4 | Q9UBU7 | 7/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21712646 | 1.00 | CDC7 (0.47) | CDC7DBF4RAB9ASMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL21712609 | 0.99 | CDC7 (0.46) | CDC7DBF4RAB9ASMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL21712612 | 0.99 | CDC7 (0.46) | CDC7DBF4RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL21712602 | 0.88 | CDC7 (0.51) | CDC7DBF4RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL21712603 | 0.88 | CDC7 (0.51) | CDC7DBF4RAB9ASMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL21712614 | 0.87 | CDC7 (0.50) | CDC7DBF4RAB9ASMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL21712615 | 0.87 | CDC7 (0.50) | CDC7DBF4RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL21712594 | 0.84 | CDC7 (0.50) | CDC7DBF4RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL21712596 | 0.84 | CDC7 (0.50) | CDC7DBF4RAB9ASMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL21712606 | 0.83 | CDC7 (0.49) | CDC7DBF4RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10745410-B2 | Substituted [5,6]cyclic-4(3H)-pyrimidinones as anticancer agents | ZENJI RESEARCH LABORATORIES (CN) | 2020-08-18 | — | — | US | claimed |
| US-20200055867-A1 | SUBSTITUTED [5,6]CYCLIC-4(3H)-PYRIMIDINONES AS ANTICANCER AGENTS | ZENJI RESEARCH LABORATORIES (CN) | 2020-02-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200055867-A1 | SUBSTITUTED [5,6]CYCLIC-4(3H)-PYRIMIDINONES AS ANTICANCER AGENTS | CDC7, CDK7, CDK17 | CDC7 1/4885DBF4 1421/4885RAB9A 2362/4885 |
| US-10745410-B2 | Substituted [5,6]cyclic-4(3H)-pyrimidinones as anticancer agents | CDC7, CDK7, CDK17 | CDC7 1/4885DBF4 1421/4885RAB9A 2362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.