Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.52 |
| ▸ | RELA | Q04206 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21743090 | 0.85 | PTPN1 (0.48) | PTPN1RAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL18085798 | 0.74 | PTPN1 (1.00) | PTPN1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL10136221 | 0.73 | PTPN1 (0.96) | PTPN1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL14160276 | 0.73 | PTPN1 (0.96) | PTPN1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL21713264 | 0.73 | PTPN1 (0.55) | PTPN1RAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL126415 | 0.72 | PTPN1 (0.87) | PTPN1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL18103163 | 0.71 | NPC1 (0.88) | PTPN1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL14715824 | 0.71 | NPC1 (0.88) | PTPN1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL3659600 | 0.69 | FFAR1 (0.89) | PTPN1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL26953087 | 0.69 | PTPN1 (0.88) | PTPN1RAB9ANPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11629137-B2 | Methods of manufacturing of niraparib | TESARO, INC. (US) | 2023-04-18 | — | — | US | disclosed |
| EP-3615513-B1 | METHODS OF MANUFACTURING OF NIRAPARIB | TESARO INC (US) | 2022-07-20 | — | — | EP | disclosed |
| US-11161834-B2 | Methods of manufacturing of niraparib | TESARO, INC. (US) | 2021-11-02 | — | — | US | disclosed |
| US-20200055837-A1 | METHODS OF MANUFACTURING OF NIRAPARIB | TESARO, INC. | 2020-02-20 | — | — | US | disclosed |
| CN-110753684-A | Method for producing nilapali | 特沙诺有限公司 | 2020-02-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200055837-A1 | METHODS OF MANUFACTURING OF NIRAPARIB | PARP2, PARP1, PARP3 | PTPN1 3196/4885RAB9A 3047/4885NPC1 4281/4885 |
| US-11161834-B2 | Methods of manufacturing of niraparib | PARP2, PARP1, PARP3 | PTPN1 3196/4885RAB9A 3047/4885NPC1 4281/4885 |
| US-11629137-B2 | Methods of manufacturing of niraparib | PARP2, PARP1, PARP3 | PTPN1 3196/4885RAB9A 3047/4885NPC1 4281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.