Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 20/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29750922 | 1.00 | HTRA1 (0.80) | HTRA1 | |
| SCHEMBL17859941 | 0.90 | HTRA1 (0.99) | HTRA1 | |
| SCHEMBL17860098 | 0.89 | HTRA1 (0.98) | HTRA1 | |
| SCHEMBL17860095 | 0.88 | HTRA1 (1.00) | HTRA1 | |
| SCHEMBL21536000 | 0.79 | HTRA1 (0.81) | HTRA1 | |
| SCHEMBL17843424 | 0.79 | HTRA1 (0.84) | HTRA1 | |
| SCHEMBL19746109 | 0.78 | HTRA1 (0.79) | HTRA1 | |
| SCHEMBL30334878 | 0.78 | HTRA1 (0.79) | HTRA1 | |
| SCHEMBL19746107 | 0.78 | HTRA1 (0.79) | HTRA1 | |
| SCHEMBL19745348 | 0.77 | HTRA1 (0.59) | HTRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7972787-B2 | determining whether the subject has a protective variant and/or a risk variant at a polymorphic site in the HTRA1 gene; slowing the progression by reducing the expression of the HTRA1 gene, or reducing the biological activity of the HTRA1 gene product | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2011-07-05 | — | — | US | disclosed |