Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 14/20 | 0.56 |
| ▸ | KDM5C | P41229 | 8/20 | 0.56 |
| ▸ | KDM5A | P29375 | 7/20 | 0.56 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.55 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.53 |
| ▸ | KDM4A | O75164 | 2/20 | 0.51 |
| ▸ | KDM6B | O15054 | 1/20 | 0.51 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26862784 | 0.87 | KDM5B (0.71) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL26862785 | 0.83 | KDM5B (0.72) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL16291539 | 0.79 | KDM5B (0.77) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL21716677 | 0.78 | KDM5B (0.74) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL21716676 | 0.76 | KDM5B (0.72) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL15637682 | 0.76 | KDM5B (0.86) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL15635919 | 0.75 | KDM5B (0.75) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL21716662 | 0.75 | KDM5B (0.84) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL16291781 | 0.75 | KDM5B (0.78) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL21716665 | 0.75 | KDM5B (0.68) | KDM5BKDM5CKDM5AKDM4CKDM5D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033377-A1 | HISTONE DEMETHYLASE 5 INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-02-13 | — | — | WO | disclosed |