Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 14/20 | 0.39 |
| ▸ | KDM5C | P41229 | 8/20 | 0.39 |
| ▸ | KDM5A | P29375 | 7/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16296605 | 0.84 | KDM5B (0.44) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL15994238 | 0.83 | KDM5B (0.43) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL15636647 | 0.83 | KDM5B (0.58) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL15994187 | 0.82 | KDM5B (0.43) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL15635733 | 0.81 | KDM5B (0.61) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL15637432 | 0.79 | KDM5B (0.45) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL15637020 | 0.77 | KDM5B (0.45) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL15636770 | 0.77 | KDM5B (0.47) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL21716672 | 0.77 | KDM5B (0.66) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL15994354 | 0.76 | KDM5B (0.56) | KDM5BKDM5CKDM5AKDM4CKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033377-A1 | HISTONE DEMETHYLASE 5 INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-02-13 | — | — | WO | disclosed |