Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 14/20 | 0.73 |
| ▸ | KDM5C | P41229 | 8/20 | 0.73 |
| ▸ | KDM5A | P29375 | 7/20 | 0.73 |
| ▸ | KDM4A | O75164 | 2/20 | 0.55 |
| ▸ | KDM6B | O15054 | 1/20 | 0.55 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.55 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.54 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21716663 | 0.85 | KDM5B (1.00) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL21716672 | 0.83 | KDM5B (0.66) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL21716662 | 0.78 | KDM5B (0.84) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16291539 | 0.75 | KDM5B (0.77) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL21716669 | 0.75 | KDM5B (0.67) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL17364565 | 0.73 | KDM5B (0.75) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL21716659 | 0.73 | KDM5B (0.64) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL26862853 | 0.72 | KDM5B (0.73) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15994347 | 0.72 | KDM5B (0.73) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL19574688 | 0.72 | KDM5B (0.69) | KDM5BKDM5CKDM5AKDM4AKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033377-A1 | HISTONE DEMETHYLASE 5 INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-02-13 | — | — | WO | disclosed |