Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | MMP2 | P08253 | 4/20 | 0.46 |
| ▸ | MMP13 | P45452 | 3/20 | 0.46 |
| ▸ | MMP1 | P03956 | 2/20 | 0.46 |
| ▸ | MMP3 | P08254 | 2/20 | 0.46 |
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | F13A1 | P00488 | 1/20 | 0.45 |
| ▸ | TGM2 | P21980 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.44 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16710257 | 0.86 | POLB (0.54) | POLBMMP2MMP13MMP1MMP3 | |
| SCHEMBL4999644 | 0.83 | POLB (0.70) | POLBMEN1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL7624989 | 0.82 | POLB (0.69) | POLBMEN1KMT2ASMN1; SMN2NAMPT | |
| SCHEMBL7624993 | 0.82 | POLB (0.69) | POLBMEN1KMT2ASMN1; SMN2NAMPT | |
| SCHEMBL13777929 | 0.78 | POLB (0.64) | POLBMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL31300398 | 0.78 | POLB (0.56) | POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2172458 | 0.78 | HTR2C (0.55) | POLBALDH1A1HPGDENPP3ENPP1 | |
| SCHEMBL2222163 | 0.78 | POLB (0.63) | POLBMEN1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL2222173 | 0.78 | POLB (0.63) | POLBMEN1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL954818 | 0.77 | POLB (0.51) | POLBMEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |