Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 10/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31677001 | 1.00 | KDM5B (0.53) | KDM5BTSHRCYP11B2PIK3CDPIK3CA | |
| SCHEMBL20074337 | 0.82 | KDM5B (0.44) | KDM5BTSHRTLR9TLR8TLR7 | |
| SCHEMBL20074140 | 0.81 | KDM5B (0.52) | KDM5BTSHRCYP11B2CYP11B1TLR9 | |
| SCHEMBL20074336 | 0.80 | KDM5B (0.47) | KDM5BTSHRCYP11B2CYP11B1TLR9 | |
| SCHEMBL31676967 | 0.80 | KDM5B (0.47) | KDM5BTSHRCYP11B2CYP11B1TLR9 | |
| SCHEMBL20074331 | 0.77 | KDM5B (0.43) | KDM5BTSHRTLR9TLR8TLR7 | |
| SCHEMBL20074099 | 0.76 | KDM5B (0.50) | KDM5BTSHR | |
| SCHEMBL20074315 | 0.76 | KDM5B (0.51) | KDM5B | |
| SCHEMBL31676960 | 0.76 | KDM5B (0.51) | KDM5B | |
| SCHEMBL20074277 | 0.75 | KDM5B (0.42) | KDM5BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975084-B2 | KDM5 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-04-13 | — | — | US | disclosed |
| US-20200048258-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048258-A1 | KDM5 INHIBITORS | KDM5A, KDM5B, KDM5C | KDM5B 2/4885TSHR 4342/4885CYP11B2 1964/4885 |
| US-10975084-B2 | KDM5 inhibitors | KDM5A, KDM5B, KDM5C | KDM5B 2/4885TSHR 4342/4885CYP11B2 1964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.