SCHEMBL21723211

SCHEMBL21723211

COC(=O)c1cc(-n2nc(S)nc2C)c(F)cc1C

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
KMT2A Q03164 4/20 0.34
TSHR P16473 2/20 0.34
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
ALDH1A1 P00352 4/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
NPC1 O15118 1/20 0.33
CASP3 P42574 1/20 0.33
RAB9A P51151 1/20 0.33
SENP8 Q96LD8 1/20 0.33
SENP7 Q9BQF6 1/20 0.33
SENP6 Q9GZR1 1/20 0.33
TTR P02766 1/20 0.32
HTT P42858 2/20 0.32
MAPT P10636 2/20 0.32
TP53 P04637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21723602 0.80 CYP1A2 (0.32) CYP1A2CYP3A4CYP2C9CYP2C19KMT2A
SCHEMBL21723360 0.75 KMT2A (0.34) KMT2ATSHRTDP1L3MBTL1ALDH1A1
SCHEMBL21723244 0.73 JMJD6 (0.41) KMT2ATSHRALDH1A1SMN1; SMN2NPC1
SCHEMBL21723192 0.71 JMJD6 (0.40) CYP1A2CYP2C9CYP2C19KMT2ATSHR
SCHEMBL27890 0.71 KDM4E (0.43) CYP1A2CYP3A4CYP2C19KMT2ATSHR
SCHEMBL21723610 0.70 TTR (0.44) TSHRL3MBTL1ALDH1A1TTRHTT
SCHEMBL21723252 0.70 JMJD6 (0.39) KMT2ATSHRL3MBTL1ALDH1A1SMN1; SMN2
SCHEMBL20470613 0.70 PDGFRB (0.42) CYP1A2CYP3A4CYP2C19KMT2ATSHR
SCHEMBL21723198 0.68 TTR (0.42) KMT2ATSHRALDH1A1SMN1; SMN2TTR
SCHEMBL31710360 0.68 CYP1A2 (0.40) CYP1A2CYP3A4CYP2C9CYP2C19KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020036133-A1 3-(1H-1,2,4-TRIAZOLE-1-YL) BENZOIC ACID AMIDE DERIVATIVE AND HARMFUL ORGANISM CONTROL AGENT クミアイ化学工業株式会社 2020-02-20 WO disclosed