⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23992762 | 0.83 | HRH3 (0.35) | — | |
| SCHEMBL25004759 | 0.83 | HRH3 (0.35) | — | |
| SCHEMBL146590 | 0.80 | — | — | |
| SCHEMBL23325922 | 0.76 | — | — | |
| SCHEMBL16300088 | 0.75 | — | — | |
| SCHEMBL681129 | 0.72 | — | — | |
| SCHEMBL21322090 | 0.71 | PIK3CD (0.44) | — | |
| SCHEMBL18775340 | 0.70 | — | — | |
| SCHEMBL24463856 | 0.70 | ATM (0.44) | — | |
| SCHEMBL21733211 | 0.70 | SLC6A4 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230293518-A1 | SUBSTITUTED PYRIDAZINONES FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES | EDGEWISE THERAPEUTICS, INC. | 2023-09-21 | — | — | US | disclosed |
| EP-3877052-B1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS INC (US) | 2023-08-16 | — | — | EP | disclosed |
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| WO-2023275199-A1 | MACROCYCLIC TAK1 INHIBITORS | AQILION AB (SE) | 2023-01-05 | — | — | WO | disclosed |
| US-20200054645-A1 | FLUORO BETA-CARBOLINE COMPOUNDS | OSSIFI THERAPEUTICS LLC | 2020-02-20 | — | — | US | disclosed |
| WO-2020037001-A1 | FLUORO β-CARBOLINE COMPOUNDS | OSTEOQC INC. (CA) | 2020-02-20 | — | — | WO | disclosed |