Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 15/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 15/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 14/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 11/20 | 0.35 |
| ▸ | CDK2 | P24941 | 11/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.33 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.33 |
| ▸ | DMPK | Q09013 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28453574 | 0.88 | AAK1 (0.41) | AAK1CDC7DBF4ROCK1CCNE1 | |
| SCHEMBL21729548 | 0.88 | AAK1 (0.41) | AAK1CDC7DBF4ROCK1CCNE1 | |
| SCHEMBL21729525 | 0.86 | AAK1 (0.40) | AAK1CDC7DBF4ROCK1CCNE1 | |
| SCHEMBL21729494 | 0.85 | AAK1 (0.45) | AAK1CDC7DBF4ROCK1CCNE1 | |
| SCHEMBL28449437 | 0.85 | AAK1 (0.45) | AAK1CDC7DBF4ROCK1CCNE1 | |
| SCHEMBL21712661 | 0.79 | CDC7 (0.41) | AAK1CDC7DBF4ROCK1CCNE1 | |
| SCHEMBL21712660 | 0.79 | CDC7 (0.41) | AAK1CDC7DBF4ROCK1CCNE1 | |
| SCHEMBL30672546 | 0.79 | CDC7 (0.41) | AAK1CDC7DBF4ROCK1CCNE1 | |
| Hydrochloric Acid SCHEMBL20572331 | 0.78 | CDC7 (0.40) | AAK1CDC7DBF4ROCK1CCNE1 | |
| Hydrochloric Acid SCHEMBL20572328 | 0.78 | CDC7 (0.40) | AAK1CDC7DBF4ROCK1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10745410-B2 | Substituted [5,6]cyclic-4(3H)-pyrimidinones as anticancer agents | ZENJI RESEARCH LABORATORIES (CN) | 2020-08-18 | — | — | US | disclosed |
| US-20200055867-A1 | SUBSTITUTED [5,6]CYCLIC-4(3H)-PYRIMIDINONES AS ANTICANCER AGENTS | ZENJI RESEARCH LABORATORIES (CN) | 2020-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200055867-A1 | SUBSTITUTED [5,6]CYCLIC-4(3H)-PYRIMIDINONES AS ANTICANCER AGENTS | CDC7, CDK7, CDK17 | AAK1 910/4885CDC7 1/4885DBF4 1421/4885 |
| US-10745410-B2 | Substituted [5,6]cyclic-4(3H)-pyrimidinones as anticancer agents | CDC7, CDK7, CDK17 | AAK1 910/4885CDC7 1/4885DBF4 1421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.