Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 17/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 12/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21731233 | 0.90 | ADORA2A (0.46) | ADORA2AADORA1ADORA2B | |
| SCHEMBL21731064 | 0.86 | ADORA2A (0.44) | ADORA2AADORA1ADORA2B | |
| SCHEMBL21731073 | 0.84 | ADORA2A (0.43) | ADORA2AADORA1ADORA2B | |
| SCHEMBL21731313 | 0.82 | ADORA2A (0.40) | MEN1KMT2AGPR55ADORA2AADORA1 | |
| SCHEMBL21731231 | 0.81 | ADORA2A (0.46) | ADORA2AADORA1ADORA2B | |
| SCHEMBL21731213 | 0.80 | ADORA2A (0.63) | MEN1KMT2AGPR55ADORA2AADORA1 | |
| SCHEMBL21731103 | 0.75 | ADORA2A (0.45) | MEN1KMT2AGPR55ADORA2AADORA1 | |
| SCHEMBL21731104 | 0.75 | ADORA2A (0.64) | MEN1KMT2AGPR55ADORA2AADORA1 | |
| SCHEMBL21731159 | 0.72 | ADORA2A (0.66) | MEN1KMT2AGPR55ADORA2AADORA1 | |
| SCHEMBL3302416 | 0.70 | MEN1 (0.51) | MEN1KMT2AGPR55ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3611174-B1 | [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVE AS A2A RECEPTOR INHIBITOR | MEDSHINE DISCOVERY INC (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3611174-A1 | [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVE AS A2A RECEPTOR INHIBITOR | Medshine Discovery Inc. (CN) | 2020-02-19 | — | — | EP | disclosed |