Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.68 |
| ▸ | TP53 | P04637 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172878 | 0.87 | TP53 (0.68) | POLBTP53MAPTNR1H4THRB | |
| SCHEMBL2172257 | 0.85 | TP53 (0.75) | POLBTP53MAPTNR1H4THRB | |
| SCHEMBL2547306 | 0.85 | MAPT (0.79) | POLBTP53MAPTNR1H4THRB | |
| SCHEMBL2172534 | 0.82 | MAPT (0.68) | POLBTP53MAPTNR1H4THRB | |
| SCHEMBL2171479 | 0.81 | POLB (0.63) | POLBTP53MAPTNR1H4THRB | |
| SCHEMBL2171108 | 0.81 | MAPT (0.79) | POLBTP53MAPTNR1H4THRB | |
| SCHEMBL2546404 | 0.79 | MAPT (0.64) | POLBTP53MAPT | |
| SCHEMBL2546880 | 0.79 | POLB (0.64) | POLBTP53MAPTNR1H4LMNA | |
| SCHEMBL2174453 | 0.79 | MAPT (0.64) | POLBTP53MAPTNR1H4 | |
| SCHEMBL2549009 | 0.79 | POLB (0.68) | POLBTP53MAPTNR1H4THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346832-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | Glaxo Group Limited (GB) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | disclosed |