Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.69 |
| ▸ | SOS1 | Q07889 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23481645 | 0.90 | KRAS (0.69) | KRASSOS1 | |
| SCHEMBL23156743 | 0.87 | KRAS (0.71) | KRASSOS1 | |
| SCHEMBL28821186 | 0.87 | KRAS (0.71) | KRASSOS1 | |
| SCHEMBL23686048 | 0.86 | KRAS (0.79) | KRASSOS1 | |
| SCHEMBL23979705 | 0.85 | KRAS (0.81) | KRASSOS1 | |
| SCHEMBL23980275 | 0.85 | KRAS (0.81) | KRASSOS1 | |
| SCHEMBL23979693 | 0.85 | KRAS (0.81) | KRASSOS1 | |
| SCHEMBL23979708 | 0.85 | KRAS (0.81) | KRASSOS1 | |
| SCHEMBL23980269 | 0.85 | KRAS (0.69) | KRASSOS1 | |
| SCHEMBL23074900 | 0.84 | KRAS (0.92) | KRASSOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035031-A1 | FUSED RING COMPOUNDS | GENENTECH, INC. (US) | 2020-02-20 | — | — | WO | disclosed |