Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.51 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.46 |
| ▸ | VHL | P40337 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21733771 | 0.91 | KRAS (0.56) | KRASSOS1 | |
| SCHEMBL21722304 | 0.91 | KRAS (0.65) | KRASSOS1VHLCDK7CCNH | |
| SCHEMBL21722256 | 0.91 | KRAS (0.65) | KRASSOS1VHLCDK7CCNH | |
| SCHEMBL30178109 | 0.91 | KRAS (0.65) | KRASSOS1VHLCDK7CCNH | |
| SCHEMBL21722294 | 0.91 | KRAS (0.65) | KRASSOS1VHLCDK7CCNH | |
| SCHEMBL21733458 | 0.91 | KRAS (0.65) | KRASSOS1VHLCDK7CCNH | |
| SCHEMBL21722279 | 0.91 | KRAS (0.65) | KRASSOS1VHLCDK7CCNH | |
| SCHEMBL21722575 | 0.91 | KRAS (0.65) | KRASSOS1VHLCDK7CCNH | |
| SCHEMBL21733460 | 0.91 | KRAS (0.65) | KRASSOS1VHLCDK7CCNH | |
| SCHEMBL30177774 | 0.91 | KRAS (0.65) | KRASSOS1VHLCDK7CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035031-A1 | FUSED RING COMPOUNDS | GENENTECH, INC. (US) | 2020-02-20 | — | — | WO | disclosed |